Jacksonville, FL: 904-953-0818

8 a.m. - 5 p.m.

Eastern time, Monday through Friday

World-Class Care for Brain Cancer Begins Here 

At Mayo Clinic, we continue to innovate so you can focus on life beyond brain cancer. We bring together a team of experts specialized in your individual tumor type who create an individualized care plan for your needs – one that includes all aspects of treatment, recovery, and quality of life. 

  • Reduced hospital stays. Many people who undergo brain tumor surgery at Mayo Clinic leave the hospital in one or two days.
  • Lower complication rates. Technological advances allow our surgeons and radiation oncologists to avoid injury to healthy brain tissue.
  • Shorter recovery time. Minimally invasive procedures often result in smaller incisions and scars.
  • Improved quality of life. We manage side effects and work to preserve and maintain motor and cognitive function, speech, cosmetic outcomes, and psychological well-being. 
  • Be seen quickly. 48 hour guaranteed access to an appointment. 

“We are always innovating at Mayo Clinic to bring our patients highly advanced treatments and a personalized, compassionate experience,” says Rich W. Byrne, M.D., a board-certified neurosurgeon and chair of Neurosurgery at Mayo Clinic in Florida.

Dr. Byrne is the Chair of Neurosurgery at Mayo Clinic Florida. He was recently named president-elect of the Society of Neurological Surgeons and has served in leadership roles in numerous professional organizations – including president of the Neurosurgical Society of America, director of the American Board of Neurological Surgery, treasurer of the Society of Neurological Surgeons, and member of the boards of directors for the American Association of Neurological Surgeons and the Congress of Neurological Surgeons.  

We operate on tumors that other centers may not. 

With our expertise and technology, we often treat people with Stage 3 or 4, or metastatic brain cancer. More than 7,000 adults and children with brain and other central nervous system cancers come to Mayo Clinic each year.


Getting a second or third opinion at Mayo Clinic for an advanced or “inoperable” tumor is about finding options and the best possible outcome for you.


“We see people who were told their tumor was highly complex or inoperable,” Dr. Byrne says. “At Mayo Clinic, we assemble a team of top experts with deep expertise in innovative approaches and perform surgeries that others can’t offer.”

Dr. Byrne’s areas of expertise and interest include:

  • Brain tumor surgery
  • Skull base surgery
  • Pituitary surgery
  • Surgical treatment for epilepsy
  • Radiosurgery  

Surgical innovations for safer procedures.  

We use advanced technologies to operate closer to vital areas of the brain with confidence and make procedures safer. These include:

  • 3-D printing, augmented reality, and holography to plan the least invasive approach to surgery.
  • Intraoperative MRI (iMRI) to map the brain and maintain functional areas.
  • Fluorescence-guided surgery to visualize the tumor’s location more precisely.
  • Minimally invasive, scarless brain surgery to enable faster recovery with fewer side effects. Approaches include key-hole surgery, radiosurgery, and laser thermal ablation. 

The power of advanced diagnostics. 

We analyze the tumor and your healthy brain tissue using advanced approaches, so we can make treatment decisions that are more precise and personalized for you.

  • Molecular diagnostics to analyze your tumor’s DNA and predict which treatments will work best for your specific tumor type.
  • Functional and metabolic activity analysis to learn about tumor metabolism and functioning of the surrounding area.
  • Tumor firmness and adhesion analysis to determine the tumor’s firmness and adhesion to healthy brain tissue, so your surgical team can plan with precision. This state-of-the art technology was invented at Mayo Clinic.  

Therapies designed to minimize side effects.

Our radiation therapies are designed to target tumor cells and minimize effects on healthy brain tissue. 

  • Stereotactic radiosurgery includes Gamma Knife®, which delivers a high dose of radiation to a very small area of the brain.

Innovative treatments and clinical trials.

Our physicians conduct research to bring advancement to patients faster with treatments and clinical trials. You can find the latest brain tumor clinical trials at  Mayo Clinic.

Research includes:

  • The most effective combination of medications and radiation therapies.
  • Investigational immunotherapy to use a patient’s own immune systems to attack their cancer.
  • Regenerative medicine approaches designed to repair brain tissue and encourage neuroregeneration. 

We’re with you every step of the way.

Our care continues after your treatment. We offer a full suite of physical, occupational, speech and other rehabilitation and recovery therapies. We also can work with your local providers on a plan designed to regain any main function lost or impaired during treatment.


If you'd like to connect with others who have or are dealing with brain cancer, our Brain Cancer Support Group is a great place to start.


Our teams in the Midwest, in Arizona, and Florida collaborate, so you get all the benefit of Mayo Clinic expertise at every location. 

When it's time to find answers, you know where to go.

Contact us to request an appointment.

Florida

4500 San Pablo Road

Jacksonville, FL 32224

904-953-0818

Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy below.

A single copy of these materials may be reprinted for noncommercial personal use only. “Mayo,” “Mayo Clinic,” “MayoClinic.org,” “Mayo Clinic Healthy Living,” and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.

© 1998-2025 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved.