Phoenix, AZ

480-301-8484

8 a.m. to 5 p.m., MST

Mayo Clinic’s MOGAD Clinic is uniquely equipped to provide accurate diagnosis and treatment for adults with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). At Mayo Clinic you’ll be seen by the world's foremost experts in MOGAD.

We conduct research toward improving diagnosis and treatment and apply proven breakthrough discoveries in our MOGAD Clinic. 

MOGAD is a newly defined autoimmune disorder that can look like multiple sclerosis (MS) or other diseases but requires different treatment. Getting a second opinion at Mayo Clinic’s MOGAD Clinic can provide peace of mind or point you to more treatment options. Our experts in MOGAD can provide a thorough evaluation and answer any questions you may have. 

Our onsite neuroimmunology laboratory performs myelin oligodendrocyte glycoprotein (MOG) antibody testing and interpretation. Since MOG antibody can be found at low levels with other disorders and create a false positive result, our MOGAD experts can determine if you truly have MOGAD. Additional tests may include MRI scans of the head, eyes and spine, a spinal tap, and an eye exam.

With MOGAD, the body's immune system attacks myelin (the outer covering of nerves), causing inflammation in the brain, optic nerve, or spinal cord. Our neurologists and radiologists are experts in approaches to treat and prevent attacks. Clinical trials are also underway at Mayo Clinic to identify effective treatments.

The MOGAD Clinic also provides comprehensive approaches to manage symptoms like vision loss, muscle weakness, stiffness or paralysis, bowel or bladder problems, confusion, seizures, and headaches. Treatments include oral corticosteroids, urology procedures, injections to control spasticity, plasma exchange, high-dose intravenous steroids, IV immunoglobulin (also called IVIg), occupational therapy, and physical therapy. 

Mayo Clinic’s MOGAD Clinic helps people with a rare, newly defined condition called myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). This is an autoimmune disorder in which the body's immune system attacks the outer covering of its nerves (myelin), leading to inflammation of the brain, optic nerve or spinal cord. Loss of this tissue is sometimes termed demyelination.

Symptoms can include vision loss, muscle weakness, stiffness or paralysis, bowel or bladder problems, confusion, seizures, and headaches. Symptoms can be confused with related disorders, such as multiple sclerosis.

Our neurologists, radiologists and neurosurgeons are experts in medical and therapeutic care for people with MOGAD. We offer treatments including:

• Oral corticosteroids
• Urology procedures
• Injections to control spasticity
• Plasma exchange
• High-dose intravenous steroids
• IV immuneglobulin ( IVIg)
• Occupational therapy
• Physical therapy

Because MOGAD can affect many parts of the body, your care team might include specialists in neurology, neuroimmunology, neuro-ophthalmology, physical medicine and rehabilitation, urology, neuropsychology, neuroradiology, pain medicine, or laboratory medicine and pathology. Your team works together to make sure you get exactly the care you need. The MOGAD Clinic at Mayo Clinic in Minnesota coordinates with a team of doctors who specialize in conditions that affect children. 

We provide MOG antibody testing and expert interpretation of results at our onsite neuroimmunology lab. 

We bring together all the specialists you may need to provide a personalized plan of care in a timely way. Your team may include specialists in neurology, neuroimmunology, neuro-ophthalmology, physical medicine and rehabilitation, urology, neuropsychology, neuroradiology, pain medicine, laboratory medicine and pathology. If you like, we can send a full report to your primary care professional or other referring healthcare professional.

This image displays the radiology scanned imaging from a 3 Tesla MRI. The 3 Tesla MRI, while using a less powerful magnetic field compared to the 7 Tesla MRI, still provides clear and detailed images of the body's interior. It is commonly used in clinical settings to diagnose and monitor various medical conditions, offering valuable insights for patient care and treatment planning. However, the clarity of the images produced by the 3 Tesla MRI is not as high as that of the 7 Tesla MRI, which can impact the level of detail visible in the scans.

This image showcases the radiology scanned imaging from a 7 Tesla MRI. This imaging system uses a stronger magnetic field to produce more detailed images of the body's interior. Detailed brain scans help Mayo Clinic care teams diagnose and treat patients with MOGAD. This advanced imaging technology is key to ensuring patients receive an accurate diagnosis to guide treatment.

Mayo Clinic in Arizona’s Neurology and Neurosurgery specialties are recognized on Newsweek’s World’s Best Specialized Hospitals 2025 list.

Mayo Clinic is top ranked in more specialties than any other hospital, according to U.S. News & World Report.

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Phoenix, AZ

5777 E. Mayo Blvd.

Phoenix, AZ 85054

480-301-8484

8 a.m. to 5 p.m. Mountain Time

Jacksonville, FL

4500 San Pablo Road

Jacksonville, FL 32224

909-953-0856

8 a.m. to 5 p.m. Eastern Time

Rochester, MN

200 First St. SW,

Rochester, MN 55905

507-284-1588

7 a.m. to 6 p.m. Central Time

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