World-class pediatric cancer care starts here.

At Mayo Clinic, your child receives the most advanced cancer care from the nation’s No. 1 hospital — where comprehensive cancer care is delivered at a renowned children's hospital. You get the best of both worlds: breakthrough treatments and compassionate, child-centered support every step of the way.

  • Swift access to expert care. We understand that every day matters. That’s why our pediatric oncology team is committed to seeing your child as soon as possible so you can move forward with confidence and a personalized care plan you can trust.
  • Care that considers your whole child. Your child is more than a diagnosis. Our experts take time to understand your family’s goals and support your child’s well-being throughout treatment and beyond. We offer the latest therapies — many designed to reduce side effects and optimize long-term outcome.
  • Pioneering treatments, hope for families. Our physician-scientists are advancing pediatric cancer care every day. Through innovative clinical trials and therapies, we give families access to the next generation of cancer treatments, bringing new hope when it's needed most.

We offer hope when it matters most.

When a child is diagnosed with advanced cancer, families turn to Mayo Clinic Children’s for answers, options and hope. Our deep experience treating the most complex pediatric cancers, combined with the latest therapies and technologies, allows us to care for children with even the rarest and most aggressive forms of cancer. Every year, thousands of families come to us seeking second —or third — opinions. Here, it’s not just about reassurance. It’s about uncovering new possibilities and giving your child the best chance at a healthy future.

The power of advanced diagnostics.

At Mayo Clinic Children’s, we combine advanced tumor genetic profiling with rapid in-house pathology to better understand your child’s cancer from the very start. By identifying the specific mutations driving the tumor, we can personalize treatment with the most effective, targeted therapies, often with fewer side effects. We move quickly from diagnosis to a tailored care plan, giving your child the best possible start on the road to recovery.

Life-prolonging therapies designed to minimize side effects. 

We’re committed to providing the most advanced, effective therapies available — delivered with the precision and care children deserve. Our approach is designed to treat cancer aggressively while protecting growing bodies. Every treatment plan is built to minimize side effects, support faster recovery, and give each child the best chance at a healthy future.

We’re the only regional center offering proton beam therapy — a highly precise form of radiation that targets the tumor while sparing healthy tissue. For growing children, this means fewer long-term side effects and better protection for developing brains, bones, and organs.

Our surgeons use advanced tools like 3D imaging and image-guided technology to remove tumors with accuracy and care — helping kids recover faster, with less impact on their developing bodies.

We personalize every treatment plan using the latest in chemotherapy, immunotherapy, and targeted biologics —reducing side effects and improving quality of life by attacking cancer cells more precisely.

We are a National Cancer Institute-Designated Comprehensive Cancer Center, which means we give families more options and more open, even when the path is complex. With access to leading-edge clinical trials and the latest therapies, we are bringing tomorrow's treatments to people with cancer today.

Some cancer treatments may affect a child’s ability to have children later in life. Our Fertility Preservation Program offers expert guidance and personalized options based on your child’s age, development, diagnosis, and treatment plan.

Innovation and Expertise You Can Trust

We care for children with all types of cancer, including some of the rarest and most complex, such as:

  • Acute leukemias and lymphomas
  • CNS tumors (brain and spinal cord)
  • Solid tumors (e.g., neuroblastoma, Wilms tumor, sarcomas)
  • High-risk, relapsed or refractory malignancies
  • Rare pediatric cancers requiring subspecialty expertise

Helping Kids Feel Like Kids — Even in the Hospital

Child Life specialists support your child’s emotional well-being through play, preparation, and age-appropriate education. We help kids and teens understand what to expect and create a more relaxed experience. Whether it's a single procedure or a longer stay, we bring comfort, uplifting moments, and guidance to help families navigate their journey with confidence.

One of the National Cancer Institute’s first designated Comprehensive Cancer Centers.

Proudly recognized for our scientific leadership and resources, providing state-of-the-art care today while developing the care of tomorrow. 

Nationally recognized for expertise.  

Mayo Clinic was one of the National Cancer Institute’s first designated comprehensive cancer centers, proudly recognized for our scientific leadership and resources. Mayo Clinic in Rochester, Minnesota, is ranked among the top hospitals in the nation for urology and for cancer by U.S. News & World Report. 

The highest standard of care, highly accessible.  

We accept most insurance plans, so the greatest number of people possible can receive the care they deserve. 

Your peace of mind is worth the trip. 

If you need to travel to Mayo Clinic for care, getting here from anywhere is easier than ever. Our dedicated travel coordination team will handle all the details, so you can stay focused on your health. We offer custom trip-planning services when you book with Patient Travel Services. 

We can help:

  • Change your flight if your appointments change.
  • Arrange hotel accommodation close to the Mayo Clinic campus.
  • Book ground transportation to help you get around.

  • Request special accommodations based upon your health condition or needs.

Get in touch today and we’ll get your itinerary started. Our agents can help you plan and tailor your trip to your needs. They’re available Monday through Friday, 8:30 a.m. to 5:30 p.m., Central Time.

Contact us to request an appointment.

Mayo Clinic in Minnesota

200 First St. SW, 

Rochester, MN 55905

507-512-1925

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